If you’re dealing with PCOS (Polycystic Ovary Syndrome), you’ve probably explored countless ways to support your hormones, energy, and overall well-being. But have you heard about NAD (Nicotinamide Adenine Dinucleotide)? This little-known but mighty coenzyme could be a game-changer for your health.
What is NAD and Why Does It Matter?
NAD is a vital coenzyme found in every cell of your body. It plays a crucial role in energy production, metabolism, and cellular repair. Think of it as the fuel that powers essential biological processes—without it, your cells wouldn’t function properly.
As we age, NAD levels naturally decline, which can lead to fatigue, metabolic imbalances, and even insulin resistance—all common issues for women with PCOS. The good news? Supplementing with NAD may help restore balance and support your body’s natural healing processes.
The Connection Between NAD and PCOS
Women with PCOS often struggle with insulin resistance, inflammation, and mitochondrial dysfunction (a fancy way of saying your cells don’t produce energy efficiently). Research suggests that NAD plays a key role in these processes:
- Improves Insulin Sensitivity: A 2019 study published in Cell Metabolism found that increasing NAD levels helped regulate glucose metabolism and reduce insulin resistance in animal models (Yoshino et al., 2019). Since insulin resistance is a hallmark of PCOS, this could be a promising benefit.
- Supports Mitochondrial Health: Mitochondria are the energy factories of your cells. Women with PCOS often have mitochondrial dysfunction, which can contribute to fatigue and weight gain. Studies suggest that boosting NAD may enhance mitochondrial function and increase energy production (Cantó et al., 2015).
- Reduces Inflammation: Chronic inflammation is another common factor in PCOS, contributing to hormonal imbalances and metabolic issues. Research has shown that NAD can activate sirtuins—proteins that help reduce inflammation and support cellular repair (Rajman et al., 2018).
The Benefits of Taking NAD Supplements
If you’re looking to naturally support your PCOS symptoms, NAD supplements might be worth considering. Here’s how they can help:
- Boost Energy Levels – More efficient mitochondria mean better energy production, which can help fight PCOS-related fatigue.
- Support Hormonal Balance – By improving insulin sensitivity and reducing inflammation, NAD may help regulate hormones.
- Aid in Weight Management – Better metabolism and mitochondrial function can support weight loss efforts.
- Enhance Cellular Repair & Longevity – NAD is essential for DNA repair and overall cellular health, keeping your body functioning optimally.
How to Increase Your NAD Levels
You can boost NAD naturally through lifestyle habits like:
- Exercise – Regular movement stimulates NAD production.
- Intermittent Fasting – This has been shown to enhance NAD levels.
- Dietary Sources – Foods like fish, dairy, and green vegetables contain precursors to NAD.
- NAD Supplements – The most direct way to increase levels is through NAD+ or NR (Nicotinamide Riboside) supplements.
Final Thoughts
PCOS can be frustrating to manage, but supporting your body with the right nutrients can make a world of difference. NAD supplements offer a science-backed way to improve insulin sensitivity, fight fatigue, and enhance overall well-being. If you’re considering adding NAD to your wellness routine, be sure to talk to your healthcare provider first!
Have you tried NAD supplements? Let us know your experience in the comments!
Disclaimer: This blog provides general wellness information and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of your physician or another qualified healthcare provider with any questions you may have regarding a medical condition or before starting any new supplement. We cannot be held responsible for any effects of taking NAD supplements.
References:
- Cantó, C., Menzies, K. J., & Auwerx, J. (2015). NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus. Cell Metabolism, 22(1), 31-53.
- Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metabolism, 27(3), 529-547.
- Yoshino, J., et al. (2019). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Cell Metabolism, 29(2), 397-400.

